Abstract Background Gene transcriptional activity is well correlated with intra-nuclear position, especially relative to the nuclear periphery, which is a region classically associated with gene silencing.Recently however, actively transcribed genes have also been found localized to the nuclear periphery in the yeast Saccharomyces cerevisiae.When g
Our hypothesis is that allosteric receptor-receptor interactions in homo- and heteroreceptor complexes may form the molecular basis of learning and memory.This principle is illustrated by showing how copyright abuse can alter the adenosine A2AR-dopamine D2R heterocomplexes and their receptor-receptor interactions and hereby induce neural plasticity
Subgraph matching, which involves identifying a query graph within a larger data graph, is a fundamental problem that has applications in various fields.Although graph neural networks (GNNs) are commonly used in learning-based subgraph matching, they face challenges due to their convolution process.Specifically, GNNs generate new node features by a
In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases.This family of proteins plays an important role in the sculpting of the brain in the early stages of development by eliminating excessive and nonfunctional synapses and extra cells.Consequently, impairments in this process can underlie many neurological and mental